Research Archive

The NIH has a new program entitled the NIH Blueprint for Neuroscience Research. This program is designed to turn discoveries into new drugs for nervous system diseases by providing a “virtual pharma” with resources, expertise and funding to advance promising compounds from chemical optimization through Phase 1 clinical testing. The network is structured so that the PI can retain ownership of the intellectual property for drugs developed within it. Disorders of interest include, but are not limited to, neurological, psychiatric and developmental disorders, dementias of aging, diseases and disorders of the eye or ear, and drug and alcohol dependence and addiction. The ultimate goals of this Neurotherapeutics Grand Challenge are to produce at least one novel and effective drug for a nervous system disorder that is currently poorly treated and to catalyze industry interest in novel disease targets by demonstrating early-stage success.
Entry requirements are the following:

  • At least one small molecule compound with strong evidence of biologic activity in a nervous system disease assay.
  • A robust, moderate throughput assay of biological activity suitable for testing compounds generated in an iterative medicinal chemistry effort.
  • Secondary bioassays and models sufficient to evaluate the potential of a drug candidate for the intended indication.

To apply, go to
The deadline is August 10, 2010

Contact Dr. Rebecca Farkas at or (301) 496-1779
for more information regarding this new initiative.